Role of Bottle gourd extract in the formulation of Detox drink: A Review on Nutritional status, Health benefits and its Utilization


Bottle gourd
health benefits

How to Cite

Goutham TM. Role of Bottle gourd extract in the formulation of Detox drink: A Review on Nutritional status, Health benefits and its Utilization. FASJ [Internet]. 2021 Apr. 30 [cited 2022 May 18];2(02):161-80. Available from:


Calabash, also known as Bottle gourd (Lagenaria siceraria), long melon or white flowered gourd belongs to the family Cucurbitaceae and is native to tropical Africa but cultivated around the warm climates in globe. It possess high amounts of water content, minerals, vitamins, lipids, amino acids and also present in abundant amounts of fiber which aids in effective weight loss. It has been reported to exhibit antibacterial, antifungal and antioxidant properties. Fresh bottle gourd juice can be used as a main constituent in the formulation of detox drink which helps to treat different diseases such as diabetes, urinary problems, hyperlipidemia, depression and cardiovascular disorders. The main objective of this Study is to explore the various aspects of Bottle gourd juice and different constituents in terms of its nutritional composition, health benefits and utilization to draw the attention of researchers as well as industrialists.



A.O. Oluduro, Evaluation of antimicrobial properties and nutritional potentials of Moringa oleifera Lam. leaf in South Western Nigeria, Malaysian Journal of Microbiology, 8(2), 2012, 59-67.

Abdrabba, Salem, and Saltana Hussein. "Chemical composition of pulp, seed and peel of red grape from Libya." Global Journal of Scientific Researches 3.2 (2015): 6-11.


Agric. Biotechnology. 2. 1-13.

AM, M. (2014). Proximate Analysis, Antioxidant and Antiproliferative Activities of Different Parts of Carica Papaya. Journal of Nutrition & Food Sciences, 04(02). doi:10.4172/2155-9600.1000267

Aravind. G, Debjit Bhowmik, Duraivel, S. Harish. G. Traditional and Medicinal Uses Of Carica Papaya. Journal of Medicinal Plant studies. 2013; 1(1):07-15.

Arkroyd WR, Gopalan C, Balasubramanuyam SC. 1966. The nutritive value of Indian food and the planning of satisfaction diet. Sept. Rep. Ser. 42 Indian Council of Medical Research. New Delhi.

Azad, A.K. (2000) Genetic diversity of jackfruit in Bangladesh and development of propagation methods. P.hd. Thesis, Univeristy of Southampton, UK.

Baliga, M. S., Shivashankara, A. R., Haniadka, R., Dsouza, J., & Bhat, H. P. (2011). Phytochemistry, nutritional and pharmacological properties of Artocarpus heterophyllus Lam (jackfruit): A review. Food Research International, 44(7), 1800–1811. doi:10.1016/j.foodres.2011.02.035

Ben Haj Koubaier, H., Snoussi, A., Essaidi, I., Chaabouni, M. M., Thonart, P., & Bouzouita, N. (2014). Betalain and Phenolic Compositions, Antioxidant Activity of Tunisian Red Beet (Beta vulgarisL.conditiva) Roots and Stems Extracts. International

Journal of Food Properties, 17(9), 1934–1945. doi:10.1080/10942912.2013.772196

Chhikara, N., Kaur, R., Jaglan, S., Sharma, P., Gat, Y., & Panghal , A. (2018). Bioactive compounds, pharmacological and food application of Syzygium cumini- a review. Food & Function. doi:10.1039/c8fo00654g.

11)Chuku, Edith. (2009). Proximate Composition of Guava Leaves (Psidium Guajava L) and Associated Field Fungi. Nigerian Journal of Mycology. 2. 65-70.

Cohen, M. (2014). Tulsi - Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and Integrative Medicine, 5(4), 251. doi:10.4103/0975-9476.146554

Devakumar, C; Dev, S. In Neem Research and Development. Randhawa, N.S; Parmar BS.; Society of Pesticide Science: India, 1993, pp. 63-96.

Dorsey, P.G., Pegg, R.B., Liao, X. & Greenspan, P. (2017). Inhibition of Non-Enzymatic Protein Glycation by Pomegranate (Punica granatum) Whole Fruit and its Components. Journal of Food Chemistry & Nanotechnology, 03.

Fantozzi, P. (1981). Grape seed: A potential source of protein. Journal of the American

Oil Chemists’ Society, 58(12), 1027–1031. doi:10.1007/bf02679319

Gunasena HPM, Ariyadasa KP, Wikramasinghe A, Herath HMW, Wikramasinghe P, Rajakaruna SB. 1996. Manual of Jack Cultivation in Sri Lanka. Forest Information Service, Forest Department: 48.

Gupta, Ravindra & Chawla, P. & Tripathi, Mridula & Shukla, A.K. & Pandey, A.. (2014). Synergistic antioxidant activity of tea with ginger, black pepper and tulsi. International Journal of Pharmacy and Pharmaceutical Sciences. 6. 477-479.

Hewlings, S., & Kalman, D. (2017). Curcumin: A Review of Its’ Effects on Human Health. Foods, 6(10), 92. doi:10.3390/foods6100092

Joshi, S., Kuszynski, C., & Bagchi, D. (2001). The Cellular and Molecular Basis of Health Benefits of Grape Seed Proanthocyanidin Extract. Current Pharmaceutical Biotechnology, 2(2), 187–200. doi:10.2174/1389201013378725.

Kale RG, Sawate AR, Kshirsagar RB, Patil BM and Mane RP Studies on evaluation of physical and chemical composition of beetroot (Beta vulgaris L.) International Journal of

Chemical Studies 2018; 6(2): 2977-2979

Keher, N.D; Negi, S.S. In Cultivation and Utilization of Medicinal Plants; Atal, C.K; Kapur, M.; Regional Research Laboratory: Jammu Tawi, 1949, pp. 483-494.

Kooti, W., & Daraei, N. (2017). A Review of the Antioxidant Activity of Celery (Apium graveolens L). Journal of Evidence-Based Complementary & Alternative Medicine, 22(4),

1029–1034. doi:10.1177/2156587217717415

23)Laily, N., Kusumaningtyas, R. W., Sukarti, I., & Rini, M. R. D. K. (2015). The Potency of Guava Psidium Guajava (L.) Leaves as a Functional Immunostimulatory Ingredient. Procedia Chemistry, 14, 301–307. doi:10.1016/j.proche.2015.03.042

Manikandan P, Murugan RS, Abbas H, Abraham SK, Nagini S. Ocimum sanctum Linn. (Holy Basil) ethanolic leaf extract protects against 7,12-dimethylbenz (a) anthraceneinduced genotoxicity, oxidative stress, and imbalance in xenobiotic-metabolizing enzymes. J Med Food 2007;10:495-502.

Modi, D.C., J.K. Patel, B.N. Shah and B.S. Nayak. 2010. Pharmacognostic studies of the seed of Syzygium cumini linn. An Int. J. Pharm. Sci., 1: 21-26.

Mohan L, Amberkar MV, Kumari M. Ocimum sanctum linn. (TULSI)-an overview. Int J Pharm Sci Rev Res 2011;7: 51-3.

Baliga, Manjeshwar Shrinath, et al. "Phytochemistry, Nutritional and Pharmacological Properties of Artocarpus Heterophyllus Lam (jackfruit): A Review." Food research international, v. 44,.7 pp. 1800-1811. doi: 10.1016/j.foodres.2011.02.035

Mondal S, Mirdha BR, Mahapatra SC. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J Physiol Pharmacol 2009;53:291-306.

Narasimham P. 1990. Breadfruit and jackfruit. In: Nagy S, Shaw PE, Wardowski WF, editors, Fruits of tropical and subtropical origin Lake Alfred, FL: Florida Science Source. p 193–259.

Nwankwo, C.. (2014). Nutritional Composition of Turmeric (Curcuma longa) and its Antimicrobial Properties. International Journal of Scientific and Engineering Research. 5. 1085 – 1089.

Nweze, Nkechinyere & Nwafor, Felix. (2014). Phytochemical, Proximate and Mineral

Composition of Leaf Extracts of Moringa oleifera Lam. from Nsukka, South-Eastern Nigeria. IOSR Journal of Pharmacy and Biological Sciences. 9. 99-103. 10.9790/3008091699103.

Odoh UE, Okoro EC. Quantitative phytochemical, proximate/nutritive composition analysis of Beta vulgaris Linnaeus (chenopodiaceae). International Journal of Current Research. 2013; 5(12):3723-3728.

Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: an overview. Journal of Nutritional Science, 5. doi:10.1017/jns.2016.41

34)Panda VS, Naik SR. Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents. Altern Med Rev 2009;14:161-71.

Pandey, Sonika & Poonia, Amrita. (2018). Bioactive compounds, medicinal benefits and value added products of ber fruit: A review. 1460-1466.

Pareek, Sunil. (2013). Nutritional composition of jujube fruit. Emirates Journal of Food and Agriculture. 25. 10.9755/ejfa.v2516.15552.

Patil, S.S., R.M. Thorat and P. Rajasekaran, 2012. Utilization of jamun fruit (Syzygium cumini) for production of red wine. J. Adv. Lab. Res. Biol., 3: 201-203.

Pattanayak, P., Behera, P., Das, D. and Panda, S.K. (2010). Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Phcog. Rev., 4:95-105.

Rivera-Pastrana, D. M., Yahia, E. M., & González-Aguilar, G. A. (2010). Phenolic and carotenoid profiles of papaya fruit (Carica papaya L.) and their contents under low temperature storage. Journal of the Science of Food and Agriculture, 90(14), 2358–2365. doi:10.1002/jsfa.4092.

Sharma, K., and Chauhan ES Akansha. "Comparative studies of proximate, mineral and phytochemical compositions of pomegranate (Punica granatum) in peel, seed and whole fruit powder." methods 17 (2018): 18.

Shivananjappa M, Joshi M. Aqueous extract of tulsi (Ocimum sanctum) enhances endogenous antioxidant defenses of human hepatoma cell line (HepG2). J Herbs Spices Med Plants 2012;18:331-48.

Shukla, Rishi Kumar, et al. "Proximate analysis, nutritive value, total phenolic content and antioxidant activity of Litchi chinensis Sonn." Nat Prod Indian J 8 (2012): 361-9.

Singh A, Kumar S, Singh IS. 1991. Functional properties of jackfruit seed flour. Lebensm – Wissu Technol 24:373–4.

Subapriya R, Bhuvaneswari V, Nagini S. Ethanolic neem (Azadirachta indica) leaf extract induces apoptosis in the

hamster buccal pouch carcinogenesis model by modulation of Bcl2, Bim, caspase 8 and caspase 3. Asian Pac J Cancer Prev. 2005 Oct-Dec;6(4):515-20.

PMID: 16436003.

Singh N, Hoette Y, Miller R. Tulsi: The Mother Medicine of Nature. 2nd ed. Lucknow:

International Institute of Herbal Medicine; 2010. p. 28-47.

46)Singh, U.P., Maurya, S. & Singh, D.P. (2005). Phenolic acids in Neem (Azadirachta indica). Journal of Herbal Pharmacotherapy , 5, 35-43.

Swami, S. B., Thakor, N. J., Haldankar, P. M., & Kalse, S. B. (2012). Jackfruit and Its Many Functional Components as Related to Human Health: A Review. Comprehensive

Reviews in Food Science and Food Safety, 11(6), 565–576. doi:10.1111/j.15414337.2012.00210.x

Tanmay KK, Shweta W, Prerna N, Awasthi OP, Charanjit K. Nutraceutical composition of Zizyphus mauritiana Lamk. (Indian Ber): effect of enzyme-assisted processing. Int J Food Sci Nutr. 2011; 62(3):276-279.

Umesh JB, Panaskar Shrimant N, Bapat VA. 2010. Evaluation of antioxidant capacity and phenol content in jackfruit (Artocarpus heterophyllus Lam.) fruit pulp. Plant Foods Hum Nutr 65:99–104.

Vongsak, B., Sithisarn, P., Mangmool, S., Thongpraditchote, S., Wongkrajang, Y., & Gritsanapan, W. (2013). Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Industrial Crops and Products, 44, 566–571. doi:10.1016/j.indcrop.2012.09.021

Wen, L., Wu, D., Jiang, Y., Prasad, K. N., Lin, S., Jiang, G., Yang, B. (2014). Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities. Journal of Functional Foods, 6, 555–563. doi:10.1016/j.jff.2013.11.022

Duke JA, Ayensu ES. Medicinal Plants of China. Algonac. MI: Reference Publications. 1985; 2: 22p.

Dhiman K, Gupta A, Sharma DK, et al. A Review on the Medicinally Important Plants of the Family Cucurbitaceae. Asian J. Clin. Nutr. 2012; 4: 16–26p.

Ghule BV, Ghante MH, Saoji AN, et al. Hypolipidemic and Antihyperlipidemic Effects of Lagenaria siceraria (Mol.) Fruit Extracts. Ind. J. Exp. Biol. 2006; 44(11): 905–909p.

Ghule BV, Ghante MH, Saoji AN, Yeole PG. Hypolipidemic and antihyperlipidemic effect of Lagenaria siceraria. Indian J Exp Biol. 2006;44:905-909.

Ghule BV, Ghante MH, Yeole PG, et al. Diuretic Activity of Lagenaria siceraria Fruit

Extracts in Rats. Indian J. Pharm. Sci. 2007; 69(6): 817–819p

57)Anonymous. The Ayurvedic Pharmacopoeia of India, Part 1. 1st ed. Vol. 1. New Delhi Civil lines, Delhi: The controller Of India, Government of India Ministry of Health and family Welfare Development of Indian System of Medicine and Homoeopathy; 2001. pp.


Deshpande JR, Choudhari AA, Mishra MR, et al. Beneficial Effects of Lagenaria siceraria

(Mol.) Standley Fruit Epicarp in Animal Models. Indian J. Exp. Biol. 2008; 46: 234–242p.

Deshpande JR, Choudhari AA, Mishra MR. Beneficial effect of Lagenaria siceraria (Mol.) standley fruit epicarp in animal models. Indian J Exp Biol. 2008;46: 234-242

Hemeda HM, Khattab HAH. The Impact of Bottle Gourd Seeds Husks on Rheological Properties of Pan Bread and Lipid Profiles in Hypercholesterolemic Rats. World Applied Sci. J. 2010; 9(7): 764–778p.

Mali V.R. and Bodhankar S.L. (2010), “Effect of Lagenaria siceraria (LS) powder on dexamethasone induced hypertension in rats” International Journal of Advances in Pharmaceutical Sciences; Vol 1 (1)

Mali VR, Bodhankar SL. Effect of Lagenaria siceraria (LS) Powder on

Dexamethasone Induced Hypertension in Rats. Int. J. Advances in Pharmaceutical Sci. 2010; 1: 1p.

Nadkarni KM. Indian Materica Medica, Volume I, A.K. Nadkarni, Popular Prakashan, 722 – 723, 1992.

Nutritional value of Bottle gourd (Lagenaria siceraria) by USDA National nutrient database

Saha P, Mazumdar UK, Haldar PK, et al. Antihyperglycemic Activity of Lageraria Siceraria Aerial Parts on Streptozotocin Induce Diabetes in Rats, Parts. Original Research Article. 2011; 40(2): 49–50p.

Saha P, Mazumder UK, Haldar PK, et al. Antioxidant and Hepatoprotective Activity of Lagenaria siceraria Aerial Parts. Pharmacognosy J. 2011; 3(22): 1p.

Saha P, Sen SK, Bala A. Evaluation of anticancer activity of Lagenaria siceraria aerial parts. Int J Canc Res. 2011;7(3): 244-253.

68)Sathaye S, Mehta BV, Sharma JB, Shaikh FM, Amin DP. Evalution of antioxidant and immunomodulatory activity of Lagenaria vulgaris. Int. J. Res. Pharm. Sci. 2011;2(3):393-298.

Sistrunk, W.A. and J.R. Morris, 1985. Quality acceptable of two cultivars of muscadine grapes mixed with other juices, J. Am. Soc. Hort. Sci., 110: 325-332.

Upaganlawar A, Balaraman R. Cardioprotective effects of Lagenaria siceraria fruit juice on isoproterenalinduced myocardial infarction in Wister Rats: A biochemical and histoar chitecture study. J Young Pharm. 2011;3(4):297–303.

Upaganlawar, A. and Balaraman, R., 2009. Bottle gourd (Lagenaria siceraria) A vegetable food for human health-a comprehensive review. Pharmacol online, 1, pp.209-226.

Van WyK BE, Gericke N. People’s Plants, a guide to useful plants of southern Africa. Briza Publications, Pretoria, 2000.

Yilmaz-Akyuz, E., Ustun-Aytekin, O., Bayram, B., & Tutar, Y. (2019). Nutrients, Bioactive Compounds, and Health Benefits of Functional and Medicinal Beverages.

Nutrients in Beverages, 175–235. doi:10.1016/b978-0-12-816842-4.00006-x.

Parle M, Kaur S. Is Bottle Gourd a Natural Guard? Int. Res. J. Pharm. 2011; 2(6): 13–17p.

(Available at

Nainwal P, Damija K, Tripathi S. Study of Antihyperlipidemic Effect of the Juice of the Fresh Fruits of Lageraria Siceraria. Int J Pharmacy and Pharmaceutical Sci. 2011; 3(1): 88–90p.

Kubde MS, Khadabadi SS, Farooqui IA, et al. Lagenaria siceraria: Phytochemistry, Pharmacognosy and Pharmacological Studies. Report Opinion. 2010; 2(3): 91– 98p.

Hussain, I., Zeb, A. and Ayub, M., 2011. Evaluation of apple and apricot blend juice preserved with sodium benzoate at refrigeration temperature.World Journal of Agricultural Sciences, 7(2), pp.136-142.

78)Bhardwaj, R.L. and Pandey, S., 2011. Juice blends—a way of utilization of under-utilized fruits, vegetables, and spices: a review. Critical reviews in food science and nutrition, 51(6), pp.563-570.

Anaga AO, Ezeja, MI, Amuzie CJ. Investigation of the Aqueous Fruit Extract of Lagenaria siceraria for Pharmacological Activities in vitro and in vivo. Int. J. Current Res. 2011; 8: 2p.

Hassanpour Fard M, Bodhankar SL, Dikshit M. Cardioprotective activity of fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin induced cardiotoxicity in rats. Int J Pharmacol 2008;6:466-71.

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